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In 2020, when the world was affected by COVID-19, we developed Orasyl Orange—a powerful mouthwash containing 1% povidone iodine. To validate its antiviral efficacy, we partnered with the Chennai Dental Research Foundation (CDRF) for a series of studies focused on the impact of povidone iodine on the SARS-CoV2 virus. The results were groundbreaking and have since been published in various respected journals.

1. Inhibitory Effect of Povidone Iodine on SARS-CoV2 Strains Across Three COVID-19 Pandemic Waves in South India

Published in the Journal of Indian Dental Association (2022), this study utilized Orasyl Orange with 1% povidone iodine to evaluate its efficacy in reducing the viral load of SARS-CoV2 in stimulated whole mouth fluid (SWMF). Researchers collected SWMF samples from 52 symptomatic COVID-19 patients and tested them at baseline, 20 minutes, and 60 minutes after gargling with Orasyl Orange.

Key Results:

  • At 20 minutes, 60% of cases showed a significant viral load reduction (1.7 log).
  • This reduction was sustained in 87% of cases at 60 minutes post-gargling.

These findings clearly demonstrate that 1% povidone iodine (Orasyl Orange) effectively reduces SARS-CoV2 viral load in the oral cavity for up to 60 minutes, significantly lowering viral transmissibility during this period.

Relevance to ORASYL: This study confirms the effectiveness of Orasyl Orange in reducing viral load, making it an essential tool in protecting against COVID-19 transmission in clinical settings and daily use.

Reference:
Rajan, Gunaseelan & Kavitha, P. & Bagavad Gita, et al. Inhibitory effect of povidone iodine on SARS-CoV2 strains across three COVID-19 pandemic waves in South India. JIDA (2022).

2. Povidone Iodine, Hydrogen Peroxide, and Chlorhexidine Mouthwashes Reduce SARS-CoV2 Burden in Whole Mouth Fluid and Respiratory Droplets

This study, published as a preprint in medRxiv (2021), assessed the antiviral efficacy of Orasyl Orange (1% povidone iodine), hydrogen peroxide, and chlorhexidine mouthwashes. Thirty-six COVID-19 positive patients were treated with these mouthwashes, and viral load in whole mouth fluid (WMF) and respiratory droplets (RD) was measured at baseline, 20 minutes, and 60 minutes post-treatment.

Key Results:

  • Orasyl Orange achieved a 92% reduction in viral load in respiratory droplets and a 50% reduction in WMF after 20 minutes.
  • This reduction was sustained up to 60 minutes.

Relevance to ORASYL: This study highlights Orasyl Orange’s potent antiviral properties, further validating its ability to significantly reduce SARS-CoV2 transmission through saliva and respiratory droplets.

Reference:
Jayaraman BG, Rajan G, Kannian P, et al. Povidone iodine, hydrogen peroxide and chlorhexidine mouthwashes reduce SARS-CoV2 burden in whole mouth fluid and respiratory droplets. medRxiv; 2021. DOI: 10.1101/2021.02.25.21252488.

3. SARS-CoV2 Antigen in Whole Mouth Fluid May Be a Reliable Rapid Detection Tool

Published in Oral Diseases (2021), this study explored the use of whole mouth fluid (WMF) as a medium for detecting SARS-CoV2 antigens through rapid antigen tests (RAT). Given the difficulties of nasopharyngeal swabs (NPS), this study tested RAT sensitivity and specificity using WMF samples from COVID-19 positive patients.

Key Results:

  • RAT using WMF had a sensitivity of 56% and a specificity of 100% compared to RT-PCR, suggesting WMF could be a viable alternative to NPS in rapid testing.

Relevance to Orasyl: In addition to its antiviral properties, Orasyl aligns with research demonstrating that WMF, which it directly interacts with, can be a reliable source for detecting viral presence, supporting its role in both prevention and testing protocols.

Reference:
Kannian P, Lavanya C, Ravichandran K, et al. SARS-CoV2 antigen in whole mouth fluid may be a reliable rapid detection tool. Oral Dis. 2022 Nov;28 Suppl 2:2575-2576. DOI: 10.1111/odi.13793.